PF-06446846 hydrochloride
PF-06446846 hydrochloride is an orally bioavailable small molecule that selectively inhibits PCSK9 synthesis by inducing ribosomal stalling during translation. This mechanism effectively lowers PCSK9 protein levels and has demonstrated activity in both cellular assays and in vivo models for cardiovascular and metabolic disease research.
Product Specifications
CAS Number
1632250-50-0
Product Name Alternative
PCSK9, PF 06446846 Hydrochloride, PF 06446846 hydrochloride, PF06446846 hydrochloride, PF06446846 Hydrochloride, PF-06446846 Hydrochloride
Purity
98.11% (May vary between batches)
Solubility
DMSO:225 mg/mL; H2O:90 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL
Smiles
Cl.Clc1cccnc1N ([C@@H]1CCCNC1) C (=O) c1ccc (cc1) -n1nnc2cccnc12
Molecular Formula
C22H20CIN7O.XHCl
Molecular Weight
470.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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