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VU0483605

VU0483605 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 1 (mGluR1), demonstrating EC50 values of 390 nM for human and 356 nM for rat receptors. This research compound is utilized in vitro and in vivo to investigate neurological pathways, synaptic plasticity, and conditions like pain and neurodegenerative diseases.

Product Specifications

CAS Number

1623101-11-0

Product Name Alternative

Brain penetrant, allosteric modulator, Inhibitor, inhibit, mGluR, mGluR1, Metabotropic glutamate receptors, metabotropic glutamate, VU 0483605, VU0483605, VU-0483605

Field of Research

Neuroscience

Purity

97.03% (May vary between batches)

Solubility

DMSO:95 mg/mL (212.68 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.39 mM)

Smiles

Clc1cccc2C (=O) N (C (=O) c12) c1ccc (NC (=O) c2ncccc2Cl) cc1Cl

Molecular Formula

C20H10Cl3N3O3

Molecular Weight

446.67

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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