VU0483605
VU0483605 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 1 (mGluR1), demonstrating EC50 values of 390 nM for human and 356 nM for rat receptors. This research compound is utilized in vitro and in vivo to investigate neurological pathways, synaptic plasticity, and conditions like pain and neurodegenerative diseases.
Product Specifications
CAS Number
1623101-11-0
Product Name Alternative
Brain penetrant, allosteric modulator, Inhibitor, inhibit, mGluR, mGluR1, Metabotropic glutamate receptors, metabotropic glutamate, VU 0483605, VU0483605, VU-0483605
Field of Research
Neuroscience
Purity
97.03% (May vary between batches)
Solubility
DMSO:95 mg/mL (212.68 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.39 mM)
Smiles
Clc1cccc2C (=O) N (C (=O) c12) c1ccc (NC (=O) c2ncccc2Cl) cc1Cl
Molecular Formula
C20H10Cl3N3O3
Molecular Weight
446.67
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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