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YS-121

YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX), with IC50 values of 3.4 μM and 6.5 μM, respectively. It dose-dependently inhibits PGE2 production (EC50=12 μM) in IL-1β-stimulated A549 cells, making it a useful research tool for studying inflammation and eicosanoid biology in cellular models.

Product Specifications

CAS Number

916482-17-2

Field of Research

Immunology & Inflammation, Metabolism Research

Smiles

N (C1=NC (SC (CCCCCC) C (O) =O) =NC (Cl) =C1) C2=C (C) C (C) =CC=C2

Molecular Formula

C20H26ClN3O2S

Molecular Weight

407.96

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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