TR antagonist 1
TR antagonist 1 is a potent small molecule inhibitor of thyroid hormone receptors, with IC50 values of 36 nM for TRα and 22 nM for TRβ. It is a valuable research tool for investigating thyroid hormone-related disorders, including hyperthyroidism and cardiac dysfunction, in both cellular and animal models.
Product Specifications
CAS Number
500794-88-7
Product Name Alternative
TR antagonist 1, THR, Thyroidhormonereceptor (THR), Thyroid hormone receptor (THR), Thyroidhormonereceptor, Thyroid hormone α, Thyroid hormone receptor, TRβ, TRα
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.57% (May vary between batches)
Solubility
DMSO:50 mg/mL (89.09 mM)
Smiles
CC (C) c1cc (Oc2c (Br) cc (CCC (O) =O) cc2Br) cc (\C=C\c2ccncc2) c1O
Molecular Formula
C25H23Br2NO4
Molecular Weight
561.26
Storage Conditions
-20°C
Notes
For research use only.
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