PG01
PG01 is a potent CFTR chloride channel potentiator effective against multiple CFTR mutants, including ΔF508, E193K, G970R, and G551D, with sub-micromolar affinity. It corrects gating defects by enhancing forskolin-stimulated chloride currents, making it a valuable research tool for in vitro cystic fibrosis studies and CFTR pharmacology investigations.
Product Specifications
CAS Number
853138-65-5
Product Name Alternative
CFTR, F508del-CFTR, PG01, PG-01, PG 01, Phenylglycine-01
Field of Research
Pharmacology & Drug Discovery
Purity
99.79% (May vary between batches)
Solubility
DMSO:30 mg/mL (68.25 mM)
Smiles
CC (C) c1ccc (NC (=O) C (N (C) C (=O) Cc2c[nH]c3ccccc23) c2ccccc2) cc1
Molecular Formula
C28H29N3O2
Molecular Weight
439.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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