GRI-977143
GRI977143 is a selective, non-lipid LPA2 receptor agonist with an EC50 of 3.3 μM. It functions as an anti-apoptotic agent by inhibiting caspases 3, 7, 8, and 9 and reducing DNA fragmentation, making it a useful research tool for studying lysophosphatidic acid signaling in models of cellular injury and survival.
Product Specifications
CAS Number
325850-81-5
Product Name Alternative
GRI 977143, GRI977143, GRI-977143, LPAReceptor, LPA Receptor, LPA2
Field of Research
Cell Biology
Purity
>98%
Bioactivity
LPA2 antagonist
Form
Powder
Solubility
Soluble in DMSO (up to 35 mg/ml)
Smiles
OC (=O) c1ccccc1SCCCN1C (=O) c2cccc3cccc (C1=O) c23
Molecular Formula
C22H17NO6S
Molecular Weight
391.44
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-[[3- (1,3-dioxo-1H-benz[de]isoquinolin-2 (3H) -yl) propyl]thio]benzoic acid
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