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CRT-0105446

CRT-0105446 is a potent and selective LIM kinase (LIMK) inhibitor. It functions by inhibiting cofilin phosphorylation, which promotes actin depolymerization, and by enhancing α-tubulin acetylation to modulate microtubule stability. This small molecule is a valuable research tool for studying cytoskeleton dynamics in cancer cell migration and neuronal development in vitro.

Product Specifications

CAS Number

1661846-05-4

Field of Research

Cell Biology

Smiles

C (F) (F) (F) C1=C (C=2C (=CC=NC2) C=3SC (NC (C (C) C) =O) =NC3) C=CC (OC) =C1

Molecular Formula

C20H18F3N3O2S

Molecular Weight

421.44

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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