Inflachromene
Inflachromene (ICM) is a small molecule inhibitor of HMGB1/2 with anti-inflammatory properties. It has been shown to reduce seizure severity in murine epilepsy models and to inhibit endothelial proliferation and autophagy in vitro via HMGB/TLR4-NF-κB and Beclin 1 pathways, making it a useful research tool for neuroinflammation and autophagy studies.
Product Specifications
CAS Number
908568-01-4
Product Name Alternative
HMGB, ICM, Inflachromene
Field of Research
Signal Transduction
Purity
97.36% (May vary between batches)
Solubility
DMSO:80 mg/mL (211.98 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.74 mM)
Smiles
CC1 (C) Oc2cc (O) ccc2C2C1=CCn1n2c (=O) n (-c2ccccc2) c1=O
Molecular Formula
C21H19N3O4
Molecular Weight
377.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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