JNJ-40418677
JNJ-40418677 is a γ-secretase modulator that selectively inhibits the γ-site cleavage of amyloid precursor protein (APP), sparing Notch processing. This selectivity makes it a valuable research tool for investigating Alzheimer's disease pathogenesis in both cellular and animal models, focusing on Aβ peptide modulation without Notch-related side effects.
Product Specifications
CAS Number
1146594-87-7
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Smiles
CC (C) C[C@H] (C (O) =O) c1cc (cc (c1) -c1ccc (cc1) C (F) (F) F) -c1ccc (cc1) C (F) (F) F
Molecular Formula
C26H22F6O2
Molecular Weight
480.44
Storage Conditions
-20°C
Notes
For research use only.
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