Gp (2′-5′) Ap (sodium)

Gp (2′-5′) Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.

Product Specifications

Product Name Alternative

Gp (2′-5′) Ap (3′) (sodium) ; 2'5'-GpAp (sodium) ; Guanylyl- (2′→5′) -3′-adenylic acid (sodium)

UNSPSC

12352005

Target

Others

Type

Oligonucleotides

Related Pathways

Others

Assay Protocol

https://www.medchemexpress.com/gp-2-5-ap-sodium.html

Purity

98.88

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](OP(OC[C@@H]2[C@@H](OP(O[Na])(O[Na])=O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4N=C3)O2)(O[Na])=O)[C@H](N5C(N=C(N)NC6=O)=C6N=C5)O[C@@H]1CO

Molecular Formula

C20H23N10Na3O14P2

Molecular Weight

758.37

References & Citations

[1]Dey RJ, Dey B, Zheng Y, et al. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. Nat Chem Biol. 2017;13 (2) :210-217.|[2]Ablasser A, Goldeck M, Cavlar T, et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013;498 (7454) :380-384.