Pemetrexed (disodium heptahydrate)

Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.

Product Specifications

CAS Number

[357166-29-1]

Product Name Alternative

LY231514 (disodium heptahydrate)

UNSPSC

12352211

Hazard Statement

H315, H319, H341, H360, H372

Target

Antifolate; Autophagy

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pemetrexed-disodium-heptahydrate.html

Concentration

10mM

Purity

99.97

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C1=CC=C(CCC2=CNC(N=C(N)N3)=C2C3=O)C=C1)=O.[7H2O]

Molecular Formula

C20H19N5Na2O6.7H2O

Molecular Weight

597.48

Precautions

H315, H319, H341, H360, H372

References & Citations

[1]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57 (6) :1116-23.|[2]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185 (2) :956-66.