Rubone
Rubone is a natural chalcone that upregulates miR-34a expression in a p53-dependent manner, leading to the downregulation of oncogenic targets like Bcl-2 and cyclin-D1. This activity inhibits tumor cell proliferation and has demonstrated efficacy in reversing chemoresistance in prostate cancer and suppressing hepatocellular carcinoma growth in preclinical models.
Product Specifications
CAS Number
73694-15-2
Product Name Alternative
2'-Hydroxy-2,4,4',5,6'-pentamethoxychalcone, Rubone
Field of Research
Epigenetics & Chromatin
Purity
98.92% (May vary between batches)
Solubility
DMSO:1 mg/mL (2.67 mM)
Smiles
C (=C/C (=O) C1=C (OC) C=C (OC) C=C1O) \C2=C (OC) C=C (OC) C (OC) =C2
Molecular Formula
C20H22O7
Molecular Weight
374.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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