Rubone
Rubone is a natural chalcone that upregulates miR-34a expression in a p53-dependent manner, leading to the downregulation of oncogenic targets like Bcl-2 and cyclin-D1. This activity inhibits tumor cell proliferation and has demonstrated efficacy in reversing chemoresistance in prostate cancer and suppressing hepatocellular carcinoma growth in preclinical models.
Product Specifications
CAS Number
73694-15-2
Product Name Alternative
2'-Hydroxy-2,4,4',5,6'-pentamethoxychalcone, Rubone
Field of Research
Epigenetics & Chromatin
Purity
98.92% (May vary between batches)
Solubility
DMSO:1 mg/mL (2.67 mM)
Smiles
C (=C/C (=O) C1=C (OC) C=C (OC) C=C1O) \C2=C (OC) C=C (OC) C (OC) =C2
Molecular Formula
C20H22O7
Molecular Weight
374.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MR208755L4V 200 µL
Smad4 (NM_008540) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details 
K0811507 1.0 µg DNA
FRA22B sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
Sign In for Pricing
View Details 
GTR15261721 1 Vial
Lentiviral mouse Brms1 shRNA (UAS) - Lentiviral mouse Brms1 shRNA (UAS, RFP) plasmid
Sign In for Pricing
View Details