SKA-111
SKA-111 is a selective KCa3.1 channel activator that binds at the CaM N-lobe/S4-S5 interface, inducing endothelial hyperpolarization. It has been utilized in vitro with porcine endothelial cells and in ex vivo studies, such as modulating Bradykinin-induced dilation in isolated rat heart coronary arteries, for cardiovascular disease research.
Product Specifications
CAS Number
1369170-24-0
Product Name Alternative
KCa3.1 channel, PotassiumChannel, Potassium Channel, SKA111, SKA-111, SKA 111
Field of Research
Pharmacology & Drug Discovery
Purity
99.79% (May vary between batches)
Solubility
DMSO:65 mg/mL (303.33 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.33 mM)
Smiles
NC1=NC=2C=3C (C (C) =CC2S1) =CC=CC3
Molecular Formula
C12H10N2S
Molecular Weight
214.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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