AZD-8835

AZD8835 is a potent and selective inhibitor of PI3Kα and PI3Kδ with IC50s of 6.2 and 5.7 nM, respectively.

Product Specifications

CAS Number

[1620576-64-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZD-8835.html

Purity

98.62

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO

Molecular Formula

C22H31N9O3

Molecular Weight

469.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Barlaam B, Discovery of 1- (4- (5- (5-amino-6- (5-tert-butyl-1,3,4-oxadiazol-2-yl) pyrazin-2-yl) -1-ethyl-1,2,4-triazol-3-yl) piperidin-1-yl) -3-hydroxypropan-1-one (AZD8835) : A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers. Bioorg Med Chem Lett. 2015 Nov 15;25 (22) :5155-62.