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ARN-6039

ARN-6039 is an orally bioavailable RORγ inverse agonist developed for autoimmune neuroinflammatory demyelinating disease research. It inhibits RORγ activity, demonstrated by an IC50 of 360 nM in a cellular reporter assay and 220 nM in suppressing IL-17 release from primary CD4+ T cells. This tool compound is used in vitro and in vivo to study Th17 cell biology and autoimmune disease mechanisms.

Product Specifications

CAS Number

1675206-11-7

Field of Research

Metabolism Research

Smiles

COc1cc2C (=O) C (Cc3ncccc3C (F) (F) F) Cc2cc1N1CCOCC1

Molecular Formula

C21H21F3N2O3

Molecular Weight

406.40

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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