ARN-6039
ARN-6039 is an orally bioavailable RORγ inverse agonist developed for autoimmune neuroinflammatory demyelinating disease research. It inhibits RORγ activity, demonstrated by an IC50 of 360 nM in a cellular reporter assay and 220 nM in suppressing IL-17 release from primary CD4+ T cells. This tool compound is used in vitro and in vivo to study Th17 cell biology and autoimmune disease mechanisms.
Product Specifications
CAS Number
1675206-11-7
Field of Research
Metabolism Research
Smiles
COc1cc2C (=O) C (Cc3ncccc3C (F) (F) F) Cc2cc1N1CCOCC1
Molecular Formula
C21H21F3N2O3
Molecular Weight
406.40
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS8111468-01 0.1 mL
Recombinant Anti-CD8 alpha Antibody, Rabbit Monoclonal
Sign In for Pricing
View Details MBS8111468-02 5x 0.1 mL
Recombinant Anti-CD8 alpha Antibody, Rabbit Monoclonal
Sign In for Pricing
View Details MBS1238825-01 0.02 mg (E-Coli)
Recombinant Chlamydia trachomatis Putative ATP:guanido phosphotransferase CT_675 (CT_675)
Sign In for Pricing
View Details MBS1238825-02 0.02 mg (Yeast)
Recombinant Chlamydia trachomatis Putative ATP:guanido phosphotransferase CT_675 (CT_675)
Sign In for Pricing
View Details MBS1238825-03 0.1 mg (E-Coli)
Recombinant Chlamydia trachomatis Putative ATP:guanido phosphotransferase CT_675 (CT_675)
Sign In for Pricing
View Details