Pralatrexate, (R) -
Pralatrexate is a folate analog antimetabolite that potently inhibits dihydrofolate reductase (DHFR) via selective uptake by the reduced folate carrier-1 (RFC-1) and intracellular polyglutamylation. It is used in research for studying anticancer mechanisms, particularly in T-cell lymphomas, and has been evaluated in both in vitro cytotoxicity assays and in vivo xenograft models.
Product Specifications
CAS Number
1320211-70-8
Field of Research
Pharmacology & Drug Discovery
Smiles
NC=1C2=C (N=CC (C[C@@H] (CC#C) C3=CC=C (C (N[C@@H] (CCC (O) =O) C (O) =O) =O) C=C3) =N2) N=C (N) N1
Molecular Formula
C23H23N7O5
Molecular Weight
477.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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