Nolatrexed dihydrochloride
Nolatrexed dihydrochloride (Thymitaq) is a water-soluble, lipophilic quinazoline folate analog that acts as a potent thymidylate synthase inhibitor, disrupting thymine synthesis and leading to DNA damage, cell cycle arrest, and apoptosis. It has been investigated in vitro and in vivo for anticancer and radiosensitizing effects in various solid tumor models.
Product Specifications
CAS Number
152946-68-4
Product Name Alternative
DNASynthesis, DNA Synthesis, AG337, AG-337, AG 337, Inhibitor, inhibit, Nolatrexed, Nolatrexed dihydrochloride, Nolatrexed Dihydrochloride, Thymitaq, Thymidylate Synthase, Thymidylate synthase, RNA Synthesis, RNASynthesis
Field of Research
Cell Biology, Molecular Biology
Purity
97.02% (May vary between batches)
Solubility
DMSO:>10 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.6 mM)
Smiles
Cl.Cl.Cc1ccc2[nH]c (N) nc (=O) c2c1Sc1ccncc1
Molecular Formula
C14H14Cl2N4OS
Molecular Weight
357.26
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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