A 80915A

A80915A is a semi-naphthoquinone antibiotic from Streptomyces aculeolatus that acts as a potent, conformation-dependent inhibitor of gastric H+/K+-ATPase. Its inhibition kinetics are slowed by potassium, which alters enzyme accessibility. This compound is used in biochemical research to study proton pump function and inhibition mechanisms in both in vitro and ex vivo gastric acid secretion models.