Berzosertib
Berzosertib (VE-822) is a potent and selective ATR inhibitor (Ki<0.2 nM) with additional activity against ATM (Ki=34 nM) . It has demonstrated antitumor efficacy in preclinical models and is under clinical investigation for various solid tumors, including ovarian and advanced solid malignancies, in both in vitro and in vivo studies.
Product Specifications
CAS Number
1232416-25-9
Product Name Alternative
Berzosertib, ATR, ATM, VX-970, VX970, VE822, VE-822, VE 822, VX 970
Field of Research
Molecular Biology, Signal Transduction
Purity
97.34% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.31 mM) ; DMSO:28 mg/mL (60.4 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CNCc1ccc (cc1) -c1cc (on1) -c1nc (cnc1N) -c1ccc (cc1) S (=O) (=O) C (C) C
Molecular Formula
C24H25N5O3S
Molecular Weight
463.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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