F-901318
Olorofim (F-901318) is a novel antifungal agent that selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), demonstrating potent activity against Aspergillus fumigatus (IC50: 44 nM) with high selectivity over the human enzyme. It shows efficacy in vitro and in vivo against various pathogenic molds, including Aspergillus, Penicillium, and Fusarium species, supporting its research in antifungal development.
Product Specifications
CAS Number
1928707-56-5
Product Name Alternative
Olorofim, F901318, F-901318, F 901318, Fungal, DHODH
Field of Research
Infectious Disease & Virology, Metabolism Research
Purity
99.28% (May vary between batches)
Solubility
DMSO: 50 mg/mL (100.29 mM), Sonication is recommended.
Smiles
C (C (NC1=CC=C (C=C1) N2CCN (CC2) C=3N=CC (F) =CN3) =O) (=O) C4=C (C=C (C) N4C) C5=CC=CC=C5
Molecular Formula
C28H27FN6O2
Molecular Weight
498.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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