FR-181877
FR-181877 is a potent, orally bioavailable nonprostanoid prostacyclin (PGI2) receptor agonist. It effectively inhibits ADP-induced human platelet aggregation in vitro (IC50 = 0.081 μM) and demonstrates favorable pharmacokinetics in rats, including a 56% oral bioavailability and a 4.3-hour half-life, supporting its utility in cardiovascular and thrombosis research.
Product Specifications
CAS Number
172936-99-1
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Smiles
C (C1=NN (C[C@@H]2CC=3C (CC2) =C (OCC (O) =O) C=CC3) C (=O) C=C1) (C4=CC=CC=C4) C5=CC=CC=C5
Molecular Formula
C30H28N2O4
Molecular Weight
480.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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