Ispronicline
Ispronicline (TC-1734) is a potent and selective partial agonist of the α4β2 nicotinic acetylcholine receptor (nAChR), exhibiting high affinity (Ki=11 nM) . This small molecule is utilized in research exploring cognitive enhancement, neuroprotection, and antidepressant mechanisms, with applications in both in vitro binding studies and in vivo behavioral models.
Product Specifications
CAS Number
252870-53-4
Product Name Alternative
RJR-1734, α4β2 nAChR, TC 01734, TC1734, TC-1734, TC 1734, TC01734, TC-01734, AZD 3480, AZD3480, AZD-3480, Ispronicline
Field of Research
Neuroscience
Purity
96.49% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.53 mM) ; DMSO:50 mg/mL (213.37 mM)
Smiles
CN[C@@H] (C) C\C=C\c1cncc (OC (C) C) c1
Molecular Formula
C14H22N2O
Molecular Weight
234.34
Storage Conditions
-20°C
Notes
For research use only.
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