J-104132

J-104132 is a potent and selective dual endothelin receptor antagonist with subnanomolar affinity for both human ETA and ETB receptors. It effectively inhibits ET-1-induced signaling in vitro and demonstrates potent oral and intravenous activity in vivo, protecting against ET-1-induced lethality in animal models, making it a valuable research tool for studying endothelin-mediated pathways.