JAK3i
JAK3i is a selective covalent inhibitor of JAK3 kinase. It potently suppresses a second, delayed wave of STAT5 phosphorylation, which is critical for T cell cycle progression and proliferation. This tool compound is used in vitro and in vivo to study JAK-STAT signaling in immunology and oncology research.
Product Specifications
CAS Number
1918238-72-8
Product Name Alternative
JAK 3i, JAK3, JAK3i, JAK-3i
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.61% (May vary between batches)
Solubility
DMSO:10 mg/mL (28.22 mM)
Smiles
C (OCC) (=O) C=1C2=C (N=CN=C2NC1) C3=CC (NC (C=C) =O) =CC=C3F
Molecular Formula
C18H15FN4O3
Molecular Weight
354.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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