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JAK3i

JAK3i is a selective covalent inhibitor of JAK3 kinase. It potently suppresses a second, delayed wave of STAT5 phosphorylation, which is critical for T cell cycle progression and proliferation. This tool compound is used in vitro and in vivo to study JAK-STAT signaling in immunology and oncology research.

Product Specifications

CAS Number

1918238-72-8

Product Name Alternative

JAK 3i, JAK3, JAK3i, JAK-3i

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.61% (May vary between batches)

Solubility

DMSO:10 mg/mL (28.22 mM)

Smiles

C (OCC) (=O) C=1C2=C (N=CN=C2NC1) C3=CC (NC (C=C) =O) =CC=C3F

Molecular Formula

C18H15FN4O3

Molecular Weight

354.34

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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