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JNJ-46356479

JNJ-46356479 is a selective, orally bioavailable positive allosteric modulator (PAM) of the mGlu2 receptor, exhibiting an EC50 of 78 nM and an Emax of 256%. This compound is a valuable research tool for investigating mGlu2 receptor function in neuropsychiatric disorders, applicable in both in vitro assays and in vivo preclinical models.

Product Specifications

CAS Number

1254979-66-2

Field of Research

Neuroscience

Smiles

C (F) (F) (F) C=1C=2N (C (CC3CC3) =NN2) C=CC1CN4CCN (CC4) C5=C (F) C=C (F) C=C5

Molecular Formula

C22H22F5N5

Molecular Weight

451.44

Storage Conditions

-20°C

Notes

For research use only.

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