K-14585
K-14585 is a selective PAR2 antagonist that inhibits PAR2-mediated NF-κB activation and IL-8 production induced by agonists like SLIGKV. Interestingly, it can elevate IL-8 levels when administered alone. This compound is a valuable research tool for studying PAR2 signaling in inflammation, cancer, and pain models, applicable in both cellular and animal studies.
Product Specifications
CAS Number
880546-17-8
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (C=1C=2C (N (CC3=C (Cl) C=CC=C3Cl) C1) =CC=C (NC (NCC (N[C@H] (C (N[C@H] (C (NC (C4=CC=CC=C4) C5=CC=CC=C5) =O) CC6=CC=CC=C6) =O) CCCCN) =O) =O) C2) N7CCCC7
Molecular Formula
C51H56Cl2N8O4
Molecular Weight
915.95
Storage Conditions
-20°C
Notes
For research use only.
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