Catharanthine
Catharanthine is a bioactive alkaloid that potently inhibits nicotinic acetylcholine receptor function, as demonstrated by its suppression of receptor-mediated diaphragm muscle contractions with an IC50 of 59.6 μM. This small molecule is a valuable research tool for studying cholinergic signaling and neuromuscular junction physiology in both in vitro and ex vivo experimental models.
Product Specifications
CAS Number
2468-21-5
Product Name Alternative
CalciumChannel, Ca channels, Ca2+ channels, Calcium Channel, Catharanthine, 3,4-Didehydrocoronaridine, 3, 4-Didehydrocoronaridine, (+) -3, 4-Didehydrocoronaridine, (+) -3,4-Didehydrocoronaridine, Inhibitor, inhibit, nAChR
Field of Research
Metabolism Research, Neuroscience, Pharmacology & Drug Discovery
Purity
99.11% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:1 mg/mL (2.97 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.81 mM) ; DMSO:40 mg/mL (118.9 mM)
Smiles
C (OC) (=O) [C@@]12[C@@]3 ([N@@] (CC (C1) (C=C3CC) [H]) CCC4=C2NC=5C4=CC=CC5) [H]
Molecular Formula
C21H24N2O2
Molecular Weight
336.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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