Stearoyl-L-carnitine (chloride)

Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM[1][2].

Product Specifications

CAS Number

[32350-57-5]

UNSPSC

12352211

Target

Endogenous Metabolite; GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/stearoyl-l-carnitine-chloride.html

Purity

99.90

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 50 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCCCCCC(O[C@@H](C[N+](C)(C)C)CC(O)=O)=O.[Cl-]

Molecular Formula

C25H50ClNO4

Molecular Weight

464.12

References & Citations

[1]Cristofano A, et, al. Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. PLoS One. 2016 May 19;11 (5) :e0155694.|[2]Carland JE, et, al. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. Br J Pharmacol. 2013 Feb;168 (4) :891-902.|[3]Huang W, et, al. Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells. Biochem Pharmacol. 1999 Oct 15;58 (8) :1361-70.