Tyroserleutide (hydrochloride)
Tyroserleutide hydrochloride is a tripeptide isolated from the degradation products of porcine spleen with antitumor activity. Tyroserleutide hydrochloride can upregulate the expression of the tumor suppressor gene PTEN and inhibit the activity of AKT and PDK1. Tyroserleutide hydrochloride inhibits tumor cell proliferation and MDM2 phosphorylation by inhibiting the PI3K/AKT pathway, and also upregulates P21, P27, P53, and induces mitochondrial damage and cell apoptosis[1][2][3].
Product Specifications
CAS Number
852982-42-4
UNSPSC
12352209
Target
Akt; Apoptosis; MDM-2/p53; PDK-1; PTEN
Type
Peptides
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tyroserleutide-hydrochloride.html
Purity
99.98
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)C[C@@H](C(O)=O)NC([C@H](CO)NC([C@@H](N)CC1=CC=C(O)C=C1)=O)=O.Cl
Molecular Formula
C18H28ClN3O6
Molecular Weight
417.88
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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