Thalidomide-O-amido-PEG2-C2-NH2 (hydrochloride)
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer[1].
Product Specifications
CAS Number
[2376990-30-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-o-amido-peg2-c2-nh2-hydrochloride.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.[H]Cl
Molecular Formula
C21H27ClN4O8
Molecular Weight
498.91
Precautions
H302, H315, H319, H335
References & Citations
[1]ARYL SULFONOHYDRAZIDES. WO 2017/176958 A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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