BMS-394136
BMS-394136 (compound 1) is a potent inhibitor of Kv 1.5, with an IC50 of 0.05 μM. BMS-394136 is a selective IKur inhibitor. BMS-394136 dose-dependently prolongs atrial effective refractory period (AERP) and action potential duration (APD) without effecting ventricular effective refractory period (VERP) . BMS-394136 can be used for acute atrial ischemia research[1].
Product Specifications
CAS Number
343246-73-1
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-394136.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(NC2=CC=NN2[C@@H]1C3=CC(Cl)=C(C=C3)Cl)C)N4[C@@H](CCC4)C5=CC=C(C=C5)F
Molecular Formula
C24H21Cl2FN4O
Molecular Weight
471.35
References & Citations
[1]Gunaga P, et al. Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4- (pyridin-2-ylmethylamino) quinazolin-2-yl]pyridine-3-sulfonamide. J Med Chem. 2017 May 11;60 (9) :3795-3803.|[2]Dezhi Xing, et al. Abstract 12964: Acute Atrial Ischemia Increases the Activity of BMS-394136, a Selective IKur Inhibitor, on Atrial Refractoriness and APD. Originally published 23 Mar 2018. Circulation. 2010;122:A12964.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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