NT113
NT113 is a brain-penetrant pan-ERBB inhibitor effective against glioblastoma models expressing wild-type EGFR or EGFRvIII. It suppresses ERBB and Akt phosphorylation in vitro and inhibits tumor growth in xenografts with EGFR amplification, supporting its research use in neuro-oncology and kinase signaling studies.
Product Specifications
CAS Number
1398833-56-1
Smiles
C (#CC=1C (NC (/C=C/CN (C) C) =O) =CC2=C (C1) N=CN=C2NC3=CC (Cl) =C (F) C=C3) [C@@H]4[C@@]5 ([C@]4 (COC5) [H]) [H]
Molecular Formula
C27H25ClFN5O2
Molecular Weight
505.97
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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