Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

666-15

666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM. 666-15 suppresses tumor growth in a breast cancer xenograft model[1][2].

Product Specifications

CAS Number

[1433286-70-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/666-15.html

Purity

99.79

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=C(Cl)C=C1O)C2=CC3=CC=CC=C3C=C2OCCNC(C4=C(OCCCN)C=C(C=CC=C5)C5=C4)=O.Cl

Molecular Formula

C33H31Cl2N3O5

Molecular Weight

620.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Xie F, et al. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015 Jun 25;58 (12) :5075-87.|[2]Zhang B, et al. C1q-TNF-related protein-3 attenuates pressure overload-induced cardiac hypertrophy by suppressing the p38/CREB pathway and p38-induced ER stress. Cell Death Dis. 2019 Jul 8;10 (7) :520.|[3]Qin Y, et al. Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer. Sci Adv. 2020 Feb 19;6 (8) :eaaw9960.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101120/666-15-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101120/666-15-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Tau (Tau 46) PE
sc-32274 PE 200 µg/mL

Tau (Tau 46) PE

Ask
View Details
MEK7 (MAP2K7) (NM_145185) Human Tagged ORF Clone
RC213868 10 µg

MEK7 (MAP2K7) (NM_145185) Human Tagged ORF Clone

Ask
View Details
F/F004B/NT-SA-PHOLUMC-200x200/1-B Fire & Disaster Signs & Labels (Adhesive)
835285 1 Pack (1 Panel (s) x 1 Pack)

F/F004B/NT-SA-PHOLUMC-200x200/1-B Fire & Disaster Signs & Labels (Adhesive)

Ask
View Details
P47/Pleckstrin Polyclonal Antibody, PerCP-Cy5.5 Conjugated
bs-9902R-PerCP-Cy5.5 100 µL

P47/Pleckstrin Polyclonal Antibody, PerCP-Cy5.5 Conjugated

Ask
View Details
Coiled Coil Domain Containing Protein 3 (CCDC3) (NM_031455) Human Untagged Clone
SC107491 10 µg

Coiled Coil Domain Containing Protein 3 (CCDC3) (NM_031455) Human Untagged Clone

Ask
View Details