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S39625

S39625 is a stable, potent, and selective topoisomerase I inhibitor that evades drug efflux transporters. It induces persistent DNA damage (γ-H2AX) and Top1 cleavage complexes at nanomolar concentrations, demonstrating potent antiproliferative activity in cancer cell lines, supporting its investigation as an anticancer agent in both in vitro and in vivo research.

Product Specifications

CAS Number

536711-20-3

Field of Research

Molecular Biology

Smiles

O=C1N2CC=3C (C2=CC4=C1CC (=O) C4 (CC) O) =NC=5C (C3C6CCC6) =CC7=C (C5) OCO7

Molecular Formula

C25H22N2O5

Molecular Weight

430.45

Storage Conditions

-20°C

Notes

For research use only.

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