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SI-2

SI-2 is a potent and selective small molecule inhibitor of the steroid receptor coactivator-3 (SRC-3/AIB1) . It effectively degrades SRC-3 protein and suppresses its transcriptional activity, inducing selective apoptosis in breast cancer cells at low nanomolar concentrations while sparing normal cells. This compound is a valuable chemical probe for studying SRC-3 biology in cancer research, supporting both in vitro and in vivo experimental applications.

Product Specifications

CAS Number

223788-33-8

Product Name Alternative

EPH116, EPH-116, EPH 116, steroid receptor coactivator-3, SI 2, SI-2, SI2

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Purity

97.85% (May vary between batches)

Solubility

DMSO:55 mg/mL (207.3 mM)

Smiles

CN1C=2C (N=C1NN=C (C) C3=CC=CC=N3) =CC=CC2

Molecular Formula

C15H15N5

Molecular Weight

265.31

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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