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SKI2496

SKI2496 is a potent, orally bioavailable antagonist of the human Gonadotropin-Releasing Hormone Receptor (hGnRHR IC50 = 0.46 nM) . It demonstrates sustained suppression of luteinizing hormone in vitro and shows species selectivity, with higher potency for human receptors over rat and monkey homologs. This profile makes it a valuable research tool for studying GnRH pathways in endocrine and oncology research.

Product Specifications

CAS Number

1308378-95-1

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Smiles

CC1=C (C (=O) N (C[C@H] (NCCCC (O) =O) C2=CC=CC=C2) C (=O) N1CC3=C (C (F) (F) F) C=CC=C3F) N4CCN (CC=5OC (C (F) (F) F) =CC5) CC4

Molecular Formula

C35H36F7N5O5

Molecular Weight

739.68

Storage Conditions

-20°C

Notes

For research use only.

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