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Ticolubant

Ticolubant is an orally bioavailable, potent antagonist of the leukotriene B4 (LTB4) receptor, exhibiting high binding affinity (Ki = 0.78 nM) and functional blockade of LTB4-induced calcium flux (IC50 = 6.6 nM) . It has demonstrated topical anti-inflammatory efficacy in murine models of skin inflammation, supporting its research use in studying LTB4-mediated pathways in neutrophil-driven inflammatory diseases.

Product Specifications

CAS Number

154413-61-3

Product Name Alternative

CalciumChannel, Calcium Channel, LTB4, Ticolubant

Field of Research

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Purity

99.33% (May vary between batches)

Solubility

DMSO:50 mg/mL (108.61 mM)

Smiles

C (=C/C (O) =O) \C1=C (OCCC2=CC=CC=C2) C=CC (CSC3=C (Cl) C=CC=C3Cl) =N1

Molecular Formula

C23H19Cl2NO3S

Molecular Weight

460.37

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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