Isosteviol

Isosteviol ((-) -Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects[1][2][3][4].

Product Specifications

CAS Number

[27975-19-5]

Product Name Alternative

(-) -Isosteviol; iso-Steviol

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Interleukin Related; Reactive Oxygen Species (ROS) ; Topoisomerase

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Isosteviol.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@]([C@]1([H])CC2)(CCC[C@@]1(C)C(O)=O)[C@@]3([H])[C@@]2(CC4=O)C[C@]4(C)CC3

Molecular Formula

C20H30O3

Molecular Weight

318.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wong KL, et al. Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat. Life Sci. 2004 Mar 26;74 (19) :2379-87.|[2]Wong KL, et al. Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells. Planta Med. 2004 Feb;70 (2) :108-12.|[3]Wong KL, et al. Antiproliferative effect of isosteviol on angiotensin-II-treated rat aortic smooth muscle cells. Pharmacology. 2006;76 (4) :163-9.|[4]Asad Ullah, et al. Bioactivity Profile of the Diterpene Isosteviol and its Derivatives. Molecules. 2019 Feb 14;24 (4) :678.