What is the catalog number for PJ34 (hydrochloride)?

The catalog number for PJ34 (hydrochloride) is HY-13688.

What sizes are available for PJ34 (hydrochloride)?

PJ34 (hydrochloride) is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 50 mg, 100 mg.

How many pack sizes does PJ34 (hydrochloride) come in?

PJ34 (hydrochloride) is available in 5 different pack sizes.

Is PJ34 (hydrochloride) in stock?

PJ34 (hydrochloride) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PJ34 (hydrochloride)?

PJ34 (hydrochloride) is manufactured by QuantiMol.

What is the estimated delivery time for PJ34 (hydrochloride)?

Estimated delivery time for PJ34 (hydrochloride) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for PJ34 (hydrochloride)?

The safety data sheet for PJ34 (hydrochloride) is available here: http://file.medchemexpress.com/batch_PDF/HY-13688/PJ34-hydrochloride-SDS-MedChemExpress.pdf.

PJ34 (hydrochloride)

PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.

Product Specifications

CAS Number

344458-15-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PJ34-hydrochloride.html

Purity

99.91

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.Cl

Molecular Formula

C17H18ClN3O2

Molecular Weight

331.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Iwashita A, et al. A novel and potent poly (ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3- (4-phenyl-3,6-dihydro-1 (2H) -pyridinyl) propyl]-4 (3H) -quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph|[2]Haddad M, et al. Anti-inflammatory effects of PJ34, a poly (ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149 (1) :23-30.|[3]Diani-Moore S, et al. NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7 (1) :2268.