Mouse Anti-Human CD54/ICAM-1-UNLB

The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 1.0 mL 100 mM borate buffered saline, pH 8.2. Store at 2-8 °C. <br>Reagents are stable for the period shown on the label if stored as directed.

Human CD54/ICAM-1<br>CD54, also known as intercellular cell adhesion molecule-1 (ICAM-1), is a 90-110 kDa type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It exhibits a wide tissue distribution, being expressed on both hematopoietic and non-hematopoietic cells. ICAM-1 expression on leukocytes is low but is rapidly upregulated upon activation. Expression on endothelium and other nonhematopoietic cells is strongly upregulated by inflammatory mediators. The ligands of ICAM-1 are CD11a/LFA-1 alpha and CD11b/Mac-1 alpha. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells (APC) contributes to antigen-specific T cell activation, presumably by enhancing interactions between T cells and APC.1-4