DBRD9 HCl
DBRD9 HCl is a PROTAC molecule that selectively degrades BRD9 with an IC50 of 56.6 nM in MOLM-13 cells, showing anti-proliferative activity in AML models. It is derived from the BRD9 ligand BI-7273 and the E3 ligase recruiter pomalidomide and exhibits high selectivity over BRD4 and BRD7.
Product Specifications
CAS Number
2341840-98-8
Product Name Alternative
Epigenetic Reader Domain, EpigeneticReaderDomain, dBRD9 HCl, dBRD9 HCl (2170679-45-3 Free base), BRD9
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Purity
99.57% (May vary between batches)
Solubility
H2O:15.4 mg/mL (17.97 mM) ; DMSO:38.5 mg/mL (44.94 mM)
Smiles
O=C1C2=C (C (C3=CC (OC) =C (CN (CC (NCCOCCOCCNC4=CC=CC (C (N5C6C (NC (CC6) =O) =O) =O) =C4C5=O) =O) C) C (OC) =C3) =CN1C) C=CN=C2.Cl.Cl
Molecular Formula
C40H47Cl2N7O10
Molecular Weight
856.75
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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