Rat Anti-Human Caspase-8-UNLB

The purified (UNLB) antibody is supplied as 0.1 mg purified immunoglobulin in 0.1 mL of 100 mM borate buffered saline, pH 8.0; store at 2-8 °C.<br>Reagents are stable for the period shown on the label if stored as directed.

Reacts with human Caspase 81<br>The Caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intraand extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis. Caspase 8 (MACH/FLICE/Mch5) is a cytosolic protease that is capable of processing/activating all known caspases, indicating its presence early in the apoptotic cascade3. It mediates cell death induction by receptors of the tumor necrosis factor (TNF) and nerve growth factor (NGF) family to eliminate injured cells and maintain leukocyte homeostasis4,5. Moreover, studies have suggested it regulates Fas-induced cytotoxicity and may have a non-apoptotic role in macrophage differentiation6,7.<br>The SB125a monoclonal antibody detects a band at ~55kD, corresponding to the full length form of Caspase 8