Mouse Anti-Human IL-21-UNLB

The purified (UNLB) antibody is supplied as 0.5mg purified immunoglobulin in 1.0mL of 100mM borate buffered saline, pH 8.2; store at 2-8 °C.<br> Reagents are stable for the period shown on the label if stored as directed.

Reacts with human IL-21<br>Interleukin-21 (IL-21) is a four helical bundle type I cytokine1. The mature form of human IL-21 is a 131 amino acid protein.4 IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells and augmentation of antitumor activity of CD8+ T cells.2, 3 Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases. Clone SB134b can be used as a capture antibody for sandwich ELISA. 5