IPSU
IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.
Product Specifications
CAS Number
1373765-19-5
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/IPSU.html
Purity
98.0
Solubility
DMSO : ≥ 30 mg/mL
Smiles
COC1=CC=NC(N(CC2)CCC2(C3=O)CCCN3CC4=CNC5=CC=CC=C54)=N1
Molecular Formula
C23H27N5O2
Molecular Weight
405.49
References & Citations
[1]Betschart C, et al. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleeparchitecture for the treatment of insomnia. J Med Chem. 2013 Oct 10;56 (19) :7590-607.|[2]Callander GE, et al. Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors. Front Neurosci. 2013 Dec 3;7:230.|[3]Hoyer D, et al. Distinct effects of IPSU and suvorexant on mouse sleep architecture.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX2 Receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNUM2027-50 1x 50 µL
CD45 / LCA (Leucocyte Marker) (PTPRC/1147 + PTPRC/1460), 1mg/mL
Sign In for Pricing
View Details 
