IPSU
IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.
Product Specifications
CAS Number
1373765-19-5
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/IPSU.html
Purity
98.0
Solubility
DMSO : ≥ 30 mg/mL
Smiles
COC1=CC=NC(N(CC2)CCC2(C3=O)CCCN3CC4=CNC5=CC=CC=C54)=N1
Molecular Formula
C23H27N5O2
Molecular Weight
405.49
References & Citations
[1]Betschart C, et al. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleeparchitecture for the treatment of insomnia. J Med Chem. 2013 Oct 10;56 (19) :7590-607.|[2]Callander GE, et al. Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors. Front Neurosci. 2013 Dec 3;7:230.|[3]Hoyer D, et al. Distinct effects of IPSU and suvorexant on mouse sleep architecture.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX2 Receptor
Available Sizes
Frequently Asked Questions
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