IPSU

IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.

Product Specifications

CAS Number

[1373765-19-5]

UNSPSC

12352005

Target

Orexin Receptor (OX Receptor)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/IPSU.html

Purity

98.0

Solubility

DMSO : ≥ 30 mg/mL

Smiles

COC1=CC=NC(N(CC2)CCC2(C3=O)CCCN3CC4=CNC5=CC=CC=C54)=N1

Molecular Formula

C23H27N5O2

Molecular Weight

405.49

References & Citations

[1]Betschart C, et al. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleeparchitecture for the treatment of insomnia. J Med Chem. 2013 Oct 10;56 (19) :7590-607.|[2]Callander GE, et al. Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors. Front Neurosci. 2013 Dec 3;7:230.|[3]Hoyer D, et al. Distinct effects of IPSU and suvorexant on mouse sleep architecture.